Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.
Behav Res Ther. 2009 May;47(5):366-73. doi: 10.1016/j.brat.2009.01.019. Epub 2009 Feb 5.
This pilot study investigated the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT), a treatment combining mindfulness meditation and interventions taken from cognitive therapy, in patients suffering from chronic-recurrent depression. Currently symptomatic patients with at least three previous episodes of depression and a history of suicidal ideation were randomly allocated to receive either MBCT delivered in addition to treatment-as-usual (TAU; N=14 completers) or TAU alone (N=14 completers). Depressive symptoms and diagnostic status were assessed before and after treatment phase. Self-reported symptoms of depression decreased from severe to mild levels in the MBCT group while there was no significant change in the TAU group. Similarly, numbers of patients meeting full criteria for depression decreased significantly more in the MBCT group than in the TAU group. Results are consistent with previous uncontrolled studies. Although based on a small sample and, therefore, limited in their generalizability, they provide further preliminary evidence that MBCT can be used to successfully reduce current symptoms in patients suffering from a protracted course of the disorder.
本试点研究调查了正念认知疗法（MBCT）的有效性，这是一种将正念冥想与认知疗法干预相结合的治疗方法，适用于患有慢性复发性抑郁症的患者。目前有症状的患者至少有三次以上的抑郁发作和自杀意念史，被随机分配接受正念认知疗法（MBCT）联合常规治疗（TAU；14 名完成者）或单独接受 TAU（14 名完成者）。在治疗前和治疗后评估抑郁症状和诊断状况。MBCT 组的抑郁症状自评从重度降至轻度，而 TAU 组则无显著变化。同样，MBCT 组符合抑郁症全部标准的患者人数也显著低于 TAU 组。研究结果与以前的非对照研究一致。尽管该研究样本量小，因此普遍性有限，但为 MBCT 可成功减轻患有慢性疾病患者的当前症状提供了进一步的初步证据。
