药用花卉。二十六。油茶花芽中酰化齐墩果烷型三萜寡糖苷、玉茶皂苷A、B、C和D的结构——胃保护、醛糖还原酶抑制和自由基清除作用——
Medicinal Flowers. XXVI. structures of acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, from the flower buds of Camellia oleifera-gastroprotective, aldose reductase inhibitory, and radical scavenging effects-.
作者信息
Sugimoto Sachiko, Chi Guihua, Kato Yasuyo, Nakamura Seikou, Matsuda Hisashi, Yoshikawa Masayuki
机构信息
Kyoto Pharmaceutical University, Yamashitaa-ku, Kyoto 607-8412, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2009 Mar;57(3):269-75. doi: 10.1248/cpb.57.269.
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia oleifera ABEL were found to exhibit inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats. The ethyl acetate- and 1-butanol-soluble fractions also showed inhibitory effects on rat lens aldose reductase and scavenging effects on 1,1-diphenylpicryl-2-hydrazyl radical and superoxide. From the 1-butanol-soluble fraction, four new acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, were isolated and their structures were elucidated on the basis of chemical and physicochemical evidence. On the other hand, quercetin 3-O-alpha-L-rhamnopyranoside and kaempferol 3-O-alpha-L-rhamnopyranoside were isolated from the ethyl acetate- and 1-butanol-soluble fractions as the principal constituents, and their gastroprotective effects were examined.
研究发现，油茶（Camellia oleifera ABEL）花蕾的甲醇提取物及其正丁醇可溶部分对乙醇和吲哚美辛诱导的大鼠胃黏膜损伤具有抑制作用。乙酸乙酯和正丁醇可溶部分对大鼠晶状体醛糖还原酶也有抑制作用，并对1,1 - 二苯基 - 2 - 三硝基苯肼自由基和超氧阴离子具有清除作用。从正丁醇可溶部分分离出了四种新的酰化齐墩果烷型三萜寡糖苷，即玉卡皂苷A、B、C和D，并根据化学和物理化学证据阐明了它们的结构。另一方面，从乙酸乙酯和正丁醇可溶部分分离出了槲皮素3 - O - α - L - 鼠李糖苷和山奈酚3 - O - α - L - 鼠李糖苷作为主要成分，并对它们的胃保护作用进行了研究。
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