Leunk R D
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
Rev Infect Dis. 1991 Jul-Aug;13 Suppl 8:S686-9. doi: 10.1093/clinids/13.supplement_8.s686.
Helicobacter pylori produces a cytotoxin that was initially detected as the ability of broth culture filtrates of this bacterium to induce intracellular vacuolation of cultured cells. Fifty-three percent of more than 200 isolates of H. pylori tested produce the cytotoxin, which appears to be unique to H. pylori. Results of characterization studies suggest that the cytotoxin is a high-molecular-weight protein. Detection of serum antibody to the cytotoxin by neutralization or immunoblotting indicates that this toxin is produced in vivo. The cytotoxin is more frequently associated with cases of peptic ulceration than with cases of gastritis; this finding suggests that the toxin contributes to the severity of disease associated with H. pylori infection.
幽门螺杆菌产生一种细胞毒素，最初是通过检测该细菌的肉汤培养滤液诱导培养细胞内空泡化的能力而发现的。在检测的200多种幽门螺杆菌分离株中，53%产生这种细胞毒素，这似乎是幽门螺杆菌所特有的。特性研究结果表明，该细胞毒素是一种高分子量蛋白质。通过中和或免疫印迹检测血清中针对该细胞毒素的抗体，表明这种毒素在体内产生。与胃炎病例相比，该细胞毒素更常与消化性溃疡病例相关；这一发现表明，该毒素会加重与幽门螺杆菌感染相关疾病的严重程度。
