[OX40和Bcl-2在变应性鼻炎中的表达]

[Expression of OX40 and Bcl-2 in allergic rhinitis].

作者信息

Zhao Jiandong, Li Wei, Wang Yanjun, Chen Xuemei

机构信息

Department of Otolaryngology, Second Affiliated Hospital, Shandong University, Jinan 270012, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Dec;22(23):1057-9.

PMID:19253527

Abstract

OBJECTIVE

To investigate the role of OX40 and Bcl-2 in allergic rhinitis(AR).

METHOD

Twenty-three subjects of allergic rhinitis as experimental group were collected and 20 subjects of deflection of nasal septum as control group. OX40 and Bcl-2 expression were examined in biopsy specimens of AR patients and nasal septum patients by immunohistochemistry respectively. The relationship between OX40 and Bcl-2 expression was analyzed.

RESULT

OX40 and Bcl-2 expression increased in the AR patients. There were positive staining not only in CD4+ T cells,but also in vascular endothelial cell, epithelial cell and glandular epithelium cell (P < 0.01). Compared with control group, the expression of OX40 (0.239 4 +/- 0.033 5) and Bcl-2 (0.237 3 +/- 0.042 1) were significantly higher than that in control group (P < 0.01). The OX40 expression was closely related to Bcl-2 expression (r = 0.869 0, P < 0.05).

CONCLUSION

The abnormal expression of costimulatory molecule OX40 is well evidenced in AR. Bcl-2 expression is likely mediated by OX40 signal pathway.

摘要

目的

探讨OX40和Bcl-2在变应性鼻炎（AR）中的作用。

方法

收集23例变应性鼻炎患者作为实验组，20例鼻中隔偏曲患者作为对照组。分别采用免疫组织化学法检测AR患者和鼻中隔患者活检标本中OX40和Bcl-2的表达情况，并分析OX40与Bcl-2表达之间的关系。

结果

AR患者中OX40和Bcl-2表达增加。不仅在CD4+T细胞中有阳性染色，在血管内皮细胞、上皮细胞和腺上皮细胞中也有阳性染色（P<0.01）。与对照组相比，OX40（0.239 4±0.033 5）和Bcl-2（0.237 3±0.042 1）的表达明显高于对照组（P<0.01）。OX40表达与Bcl-2表达密切相关（r=0.869 0，P<0.05）。