Slobodeniuk V K, Glinskikh N P, Grigor'eva Iu V, Tulakina L G, Pashnina N I, Patsuk N V, Rumako E N
Vopr Virusol. 2009 Jan-Feb;54(1):33-6.
The neuropathogenicity of Coxsackie B3, B1, and B5 virus strains was studied in experimentally infected suckling BALB/c mice and in contact animals from the same nest and litter infected due to the natural virus spread. The similar neurological disorders were found in both groups of animals. The data on pathological and morphological changes in the medulla oblongata as dystrophic and necrotic changes in the neurons with their lysis and deletion, brain tissue edema, and hemodynamic changes confirmed the neutrotropicity of the strains under study. The revealed pattern of brain lesions did not depend on the time of isolation of the viral strains being examined.
在实验感染的乳鼠BALB/c小鼠以及因自然病毒传播而感染的同窝和同胎接触动物中，研究了柯萨奇B3、B1和B5病毒株的神经致病性。在两组动物中均发现了相似的神经功能障碍。关于延髓病理和形态学变化的数据，如神经元的营养不良和坏死变化及其溶解和缺失、脑组织水肿和血流动力学变化，证实了所研究病毒株的嗜神经性。所揭示的脑损伤模式并不取决于所检测病毒株的分离时间。
