Molé C, Thomas P, Bene M C, Tamisier J N, Faure G C
Laboratoire d'Immunologie, Faculté de Médecine de Nancy.
Rev Rhum Mal Osteoartic. 1991 Jul-Sep;58(7):507-11.
Rheumatoid factors of the IgA isotype directed to human IgG Fc fragment were assayed, using an Elisa test, in the serum of 30 patients with seropositive rheumatoid arthritis and in the synovial fluid of 9 of them. A high incidence was found in the serum (90%) and synovial fluids (77%). Clinical, radiological and biological parameters of each patients were recorded at the time of the assay, and two years later. There was no statistically significant association between IgA rheumatoid factors levels and other parameters, nor with a pejorative evolution. However, a significant negative correlation was observed between IgA rheumatoid factors levels and the duration of the disease, suggesting that IgA rheumatoid factors are predominantly produced at the earliest stages of rheumatoid arthritis.
采用酶联免疫吸附测定法，对30例血清反应阳性类风湿性关节炎患者的血清以及其中9例患者的滑液进行检测，以测定针对人IgG Fc片段的IgA同种型类风湿因子。结果发现，血清（90%）和滑液（77%）中的发生率较高。在检测时以及两年后，记录了每位患者的临床、放射学和生物学参数。IgA类风湿因子水平与其他参数之间，以及与病情恶化之间均无统计学显著关联。然而，观察到IgA类风湿因子水平与疾病持续时间之间存在显著负相关，这表明IgA类风湿因子主要在类风湿性关节炎的最早阶段产生。
