右美托咪定与阿托品联合应用对猫心肺功能影响的评估。
Evaluation of cardiorespiratory effects of combinations of dexmedetomidine and atropine in cats.
作者信息
Monteiro Eduardo R, Campagnol Daniela, Parrilha Letícia R, Furlan Luísa Z
机构信息
Faculdade de Medicina Veterinária, Centro Universitário de Vila Velha (UVV), Vila Velha-ES, Brazil.
出版信息
J Feline Med Surg. 2009 Oct;11(10):783-92. doi: 10.1016/j.jfms.2008.12.008. Epub 2009 Feb 28.
Abstract
The cardiovascular effects of dexmedetomidine alone or in combination with atropine were studied in six cats. Cats underwent four treatments in a randomized crossover design as follows: DEX15, saline+dexmedetomidine 15microg/kg; DEX30, saline+dexmedetomidine 30microg/kg; ADEX15, atropine+dexmedetomidine 15microg/kg; ADEX30, atropine+dexmedetomidine 30microg/kg. Pulse rate (PR) and systolic arterial pressure (SAP) decreased in DEX15 and DEX30. Premedication with atropine was effective in preventing bradycardia (PR<100 beats/min) and resulted in a biphasic effect in blood pressure. Hypertension was followed by a gradual decrease in SAP. Rate pressure product decreased in DEX15 and DEX30 whereas in ADEX15 and ADEX30 it remained within baseline values for at least 60min. Although premedication with atropine in cats sedated with dexmedetomidine prevents bradycardia, it induces hypertension and increases myocardial oxygen consumption. The magnitude of cardiovascular effects produced by dexmedetomidine in cats does not seem to be dose-related.
摘要
在六只猫身上研究了右美托咪定单独使用或与阿托品联合使用时的心血管效应。猫采用随机交叉设计接受以下四种治疗：DEX15，生理盐水+右美托咪定15μg/kg；DEX30，生理盐水+右美托咪定30μg/kg；ADEX15，阿托品+右美托咪定15μg/kg；ADEX30，阿托品+右美托咪定30μg/kg。DEX15和DEX30组的心率（PR）和收缩压（SAP）降低。阿托品预处理可有效预防心动过缓（PR<100次/分钟），并对血压产生双相效应。高血压之后是SAP逐渐下降。DEX15和DEX30组的心率血压乘积降低，而ADEX15和ADEX30组至少60分钟内保持在基线值范围内。虽然在右美托咪定镇静的猫中使用阿托品预处理可预防心动过缓，但它会诱发高血压并增加心肌耗氧量。右美托咪定在猫身上产生的心血管效应程度似乎与剂量无关。
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