亚硝基硫醇的意外双连接
An unexpected Bis-ligation of S-nitrosothiols.
作者信息
Zhang Jiming, Wang Hua, Xian Ming
机构信息
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
出版信息
J Am Chem Soc. 2009 Mar 25;131(11):3854-5. doi: 10.1021/ja900370y.
PMID:19256495
Abstract
A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.
摘要
已开发出一种使用三芳基取代的膦硫酯底物对S-亚硝基硫醇进行双连接反应的方法。该反应在温和条件下能将不稳定的伯S-亚硝基硫醇高产率地转化为稳定的二硫化物-亚氨基磷烷产物。它有可能应用于蛋白质系统中亚硝化作用的检测。
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