Zhang Jiming, Wang Hua, Xian Ming
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
J Am Chem Soc. 2009 Mar 25;131(11):3854-5. doi: 10.1021/ja900370y.
A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.
已开发出一种使用三芳基取代的膦硫酯底物对S-亚硝基硫醇进行双连接反应的方法。该反应在温和条件下能将不稳定的伯S-亚硝基硫醇高产率地转化为稳定的二硫化物-亚氨基磷烷产物。它有可能应用于蛋白质系统中亚硝化作用的检测。
Zotero 插件