Sonnen Joshua A, Larson Eric B, Gray Shelly L, Wilson Angela, Kohama Steven G, Crane Paul K, Breitner John C S, Montine Thomas J
Department of Pathology, University of Washington, Seattle, USA.
Ann Neurol. 2009 Feb;65(2):226-9. doi: 10.1002/ana.21508.
Evidence supports a pathogenic role for free radical injury to brain in Alzheimer's disease; however, clinical trial results are only mildly encouraging. Examining brains from The Adult Changes in Thought study offers a unique perspective. Selectively increased free radical damage to cerebral cortex was associated with Alzheimer's disease, microvascular brain injury, and current smoking, but not with antioxidant supplement usage. Our results support suppression of free radical injury to brain as a therapeutic target for Alzheimer's disease and microvascular brain injury; however, future clinical trials should consider other antioxidants or doses than those identified in our study.
有证据支持自由基对阿尔茨海默病大脑的损伤具有致病作用；然而，临床试验结果仅略显乐观。对“成人思维变化研究”中的大脑进行检查提供了一个独特的视角。大脑皮层自由基损伤的选择性增加与阿尔茨海默病、微血管脑损伤和当前吸烟有关，但与抗氧化剂补充剂的使用无关。我们的结果支持将抑制大脑自由基损伤作为阿尔茨海默病和微血管脑损伤的治疗靶点；然而，未来的临床试验应考虑使用我们研究中未确定的其他抗氧化剂或剂量。
