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阿尔茨海默病可改变风险因素的人群归因分数：系统评价的系统综述

Population attributable fraction of modifiable risk factors for Alzheimer disease: A systematic review of systematic reviews.

作者信息

Hazar Narjes, Seddigh Leila, Rampisheh Zahra, Nojomi Marzieh

机构信息

Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Department of Community Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Neurol. 2016 Jul 6;15(3):164-72.

PMID:27648178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5027152/
Abstract

BACKGROUND

Alzheimer's disease (AD) is the most common type of dementia. Demonstrating the modifiable risk factors of AD can help to plan for prevention of this disease. The aim of the current review was to characterize modifiable cardiovascular risk factors of AD using existing data and determine their contribution in AD development in Iran and the world.

METHODS

The systematic search was done in Medline, Scopus, and Cochrane databases from inception to May 2014 to find systematic reviews or meta-analyses about association between AD and cardiovascular modifiable risk factors included diabetes, hypertension (HTN), physical inactivity, smoking, hypercholesterolemia, and overweight and obesity. The population attributable fraction (PAF) was calculated for these risk factors in Iran and the world.

RESULTS

Of 2651 articles, 11 were eligible for data extraction after assessing relevancy and quality. Diabetes mellitus (DM) type 2, smoking, physical inactivity, overweight and obesity were significantly associated with increased risk of AD. Physical inactivity with 22.0% and smoking with 15.7% had the highest PAF for AD in Iran and the world, respectively.

CONCLUSION

Our findings demonstrated that modifiable cardiovascular risk factors could increase the risk of AD. Moreover, about one-third of AD cases were attributed to five modifiable risk factors.

摘要

背景

阿尔茨海默病（AD）是最常见的痴呆类型。阐明AD的可改变风险因素有助于制定该病的预防计划。本综述的目的是利用现有数据描述AD的可改变心血管风险因素，并确定它们在伊朗和全球AD发病中的作用。

方法

从数据库建立至2014年5月，在Medline、Scopus和Cochrane数据库中进行系统检索，以查找关于AD与心血管可改变风险因素（包括糖尿病、高血压（HTN）、身体活动不足、吸烟、高胆固醇血症以及超重和肥胖）之间关联的系统评价或荟萃分析。计算了这些风险因素在伊朗和全球的人群归因分数（PAF）。

结果

在2651篇文章中，经相关性和质量评估后，有11篇符合数据提取条件。2型糖尿病（DM）、吸烟、身体活动不足、超重和肥胖与AD风险增加显著相关。身体活动不足和吸烟在伊朗和全球对AD的PAF最高，分别为22.0%和15.7%。

结论

我们的研究结果表明，可改变的心血管风险因素会增加AD风险。此外，约三分之一的AD病例可归因于五个可改变风险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f5f/5027152/77343840f476/IJNL-15-164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f5f/5027152/77343840f476/IJNL-15-164-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f5f/5027152/77343840f476/IJNL-15-164-g001.jpg

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1
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2
When aging-onset diabetes is coming across with Alzheimer disease: comparable pathogenesis and therapy.当老年发病型糖尿病与阿尔茨海默病相遇：相似的发病机制和治疗方法。
Exp Gerontol. 2013 Aug;48(8):744-50. doi: 10.1016/j.exger.2013.04.013. Epub 2013 May 4.
3
Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias.
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4
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Neurology. 2024 Feb 13;102(3):e208116. doi: 10.1212/WNL.0000000000208116. Epub 2024 Jan 17.
5
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6
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7
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9
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10
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