White J M L, McFadden J P, White I R
Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK.
Br J Dermatol. 2008 Mar;158(3):518-21. doi: 10.1111/j.1365-2133.2007.08391.x. Epub 2008 Jan 17.
Active patch test sensitization is an uncommon phenomenon which may have undesirable consequences for those undergoing this gold-standard investigation for contact allergy.
To perform a retrospective analysis of the results of 241 subjects who were patch tested twice in a monocentre evaluating approximately 1500 subjects per year.
Positivity to 11 common allergens in the recommended Baseline Series of contact allergens (European) was analysed: nickel sulphate; Myroxylon pereirae; fragrance mix I; para-phenylenediamine; colophonium; epoxy resin; neomycin; quaternium-15; thiuram mix; sesquiterpene lactone mix; and para-tert-butylphenol resin.
Only fragrance mix I gave a statistically significant, increased rate of positivity on the second reading compared with the first (P=0.011). This trend was maintained when separately analysing a subgroup of 42 subjects who had been repeat patch tested within 1 year; this analysis was done to minimize the potential confounding factor of increased usage of fragrances with a wide interval between both tests. To reduce the confounding effect of age on our data, we calculated expected frequencies of positivity to fragrance mix I based on previously published data from our centre. This showed a marked excess of observed cases over predicted ones, particularly in women in the age range 40-60 years.
We suspect that active sensitization to fragrance mix I may occur. Similar published analysis from another large group using standard methodology supports our data.
主动斑贴试验致敏是一种罕见现象，对于那些接受这种接触性过敏金标准检查的人可能会产生不良后果。
对在单中心每年约1500名受试者中进行两次斑贴试验的241名受试者的结果进行回顾性分析。
分析了推荐的欧洲接触性变应原基线系列中11种常见变应原的阳性率：硫酸镍；秘鲁香脂；香料混合物I；对苯二胺；松香；环氧树脂；新霉素；季铵盐-15；秋兰姆混合物；倍半萜内酯混合物；对叔丁基苯酚树脂。
与第一次读数相比，只有香料混合物I在第二次读数时阳性率有统计学意义的增加（P=0.011）。在单独分析42名在1年内重复进行斑贴试验的亚组时，这种趋势得以维持；进行该分析是为了尽量减少两次试验间隔时间长导致香料使用增加这一潜在混杂因素的影响。为了减少年龄对我们数据的混杂影响，我们根据本中心先前发表的数据计算了香料混合物I阳性的预期频率。结果显示观察到的病例明显超过预测病例，尤其是在40至60岁的女性中。
我们怀疑可能会发生对香料混合物I的主动致敏。另一大组使用标准方法发表的类似分析支持了我们的数据。
