善、恶与丑：从正常淋巴管生成到肿瘤相关淋巴管生成的神经纤毛蛋白-2的故事
The good, the bad and the ugly: a neuropilin-2 story from normal to tumor-associated lymphangiogenesis.
作者信息
Roth Lise
机构信息
INSERM U575 Centre de Neurochimie, Strasbourg, France.
出版信息
Cell Adh Migr. 2008 Oct-Dec;2(4):217-9. doi: 10.4161/cam.2.4.6960. Epub 2008 Oct 9.
Abstract
VEGF-C is a crucial player in lymphangiogenesis. Besides VEGFR-2 and VEGFR-3, it also binds NRP2. NRP2 enhances VEGF-C/VEGFR-3 effects in developmental lymphangiogenesis, but its role in adult and tumoral lymphangiogenesis is not known. In their study, Bagri and colleagues demonstrate that blocking NRP2 results in a decrease of metastasis formation, a phenomenon relying on tumoral lymphangiogenesis. Thus, they identified NRP2 as an attractive new target for modulating metastasis.
摘要
血管内皮生长因子C（VEGF-C）是淋巴管生成中的关键因子。除了血管内皮生长因子受体2（VEGFR-2）和血管内皮生长因子受体3（VEGFR-3）外，它还与神经纤毛蛋白2（NRP2）结合。NRP2在发育性淋巴管生成中增强VEGF-C/VEGFR-3的作用，但其在成人和肿瘤性淋巴管生成中的作用尚不清楚。在他们的研究中，巴格里及其同事证明，阻断NRP2会导致转移形成减少，这一现象依赖于肿瘤性淋巴管生成。因此，他们将NRP2确定为调节转移的一个有吸引力的新靶点。
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