Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada.
Eye Contact Lens. 2009 Mar;35(2):92-7. doi: 10.1097/ICL.0b013e318199df54.
To assess the compatibility of a new silicone hydrogel lens, asmofilcon A (with four multipurpose disinfecting solutions: OPTIFREE RepleniSH, ReNu MultiPlus, Solo-Care Aqua and MeniCare Soft). Ocular responses and subjective responses were monitored with each lens-care system combination.
The study was conducted as a prospective, bilateral, clinical trial with a single-masked investigator, and randomized cross-over design with four phases, (one for each care system). Each study phase comprised of two consecutive days of lens wear where the lenses were inserted on day 1 directly from the blister-packs and worn for over 8 hr, then inserted on day 2 after overnight disinfection with one of the study lens care systems. Twenty-five adapted soft contact lens wearers who were able to wear their habitual lenses comfortably for more than 12 hr were recruited.
There were statistically significant differences in corneal staining found for all the lens-care systems when comparing the results of day 1 (from the blister pack) with day 2 (following care system use) (P < 0.05). ReNu MultiPlus solution had the highest grade for corneal staining at the 2-hr time point on day 2 which then decreased by 6 hr (P < 0.05). There was no difference between the lens care systems and the rating of subjective comfort over either of the two days. The rating of dryness and burning sensations were only slightly increased at 6 hr for all lens care systems except ReNu MultiPlus where burning was highest on insertion (P < 0.05).
Corneal staining observed in this study does not seem to have been related to the presence of polyhexamethylene biguanide (0.0001% wv) that was present in three of the four care systems. Only one care system (ReNu MultiPlus) demonstrated an associated level of corneal staining that was statistically significant; however, this was not considered to be of clinical relevance. These results suggest that using this novel surface-treated silicone hydrogel lens may result in less lens and lens care-related interactions.
评估一种新型硅水凝胶隐形眼镜（阿姆斯菲康 A）与四种多功能消毒溶液（OPTIFREE RepleniSH、ReNu MultiPlus、Solo-Care Aqua 和 MeniCare Soft）的兼容性。使用每种镜片护理系统组合监测眼部反应和主观反应。
本研究采用前瞻性、双侧、单盲研究者、随机交叉设计进行，共分为四个阶段（每个护理系统一个阶段）。每个研究阶段包括连续两天的镜片佩戴，第一天直接从泡罩包装中插入镜片，佩戴超过 8 小时，然后在第二天使用其中一种研究镜片护理系统过夜消毒后插入。招募了 25 名适应软性隐形眼镜的佩戴者，他们能够舒适地佩戴他们的习惯性镜片超过 12 小时。
所有镜片护理系统在比较第一天（从泡罩包装中）与第二天（使用护理系统后）的角膜染色结果时，均存在统计学上的显著差异（P<0.05）。ReNu MultiPlus 溶液在第二天 2 小时时的角膜染色等级最高，然后在 6 小时时降低（P<0.05）。在两天中的任何一天，镜片护理系统和主观舒适度的评分都没有差异。除了 ReNu MultiPlus 溶液在插入时烧灼感最高外，所有镜片护理系统在 6 小时时的干燥和烧灼感评分仅略有增加（P<0.05）。
本研究中观察到的角膜染色似乎与四种护理系统中存在的聚六亚甲基双胍（0.0001% wv）无关。只有一种护理系统（ReNu MultiPlus）显示出与统计学显著相关的角膜染色水平；然而，这被认为没有临床意义。这些结果表明，使用这种新型表面处理的硅水凝胶隐形眼镜可能会减少镜片和镜片护理相关的相互作用。
