Grewal A S, Rouse B T, Babiuk L A
Infect Immun. 1977 Mar;15(3):698-703. doi: 10.1128/iai.15.3.698-703.1977.
Enriched populations of polymorphonuclear leukocytes (PMN) and macrophages obtained from the mammary gland and of granulocytes (PBG) and lymphocytes (PBL) prepared from peripheral blood of the same animal were compared for their ability to mediate antibody-dependent cell cytotoxocity against antibody-sensitized infectious bovine rhinotracheitis virus-infected target cells (IBR-GBK) and antibody-sensitized chicken erythrocyte targest (CRBC). The order of effectiveness was PMN leads to macrophages leads to PBG leads to PBL. The reason why PBG (86% PMN) were less than 50% as active as mammary PMN (99% PMN) was explored and discussed. The findings that PMN were more effective on a cell-to-cell basis, required less antiserum to sensitize for cytotoxicity, and destroyed IBR-GBK cells faster and more completely than other cell types could mean that PMN may be the cell type most importnat in causing early recovery from herpesvirus infections.
对从同一动物乳腺获得的多形核白细胞（PMN）和巨噬细胞以及从外周血制备的粒细胞（PBG）和淋巴细胞（PBL）的富集群体，比较它们介导针对抗体致敏的感染牛传染性鼻气管炎病毒的靶细胞（IBR - GBK）和抗体致敏的鸡红细胞靶细胞（CRBC）的抗体依赖性细胞毒性的能力。有效性顺序为PMN＞巨噬细胞＞PBG＞PBL。探讨并讨论了PBG（86%为PMN）的活性不及乳腺PMN（99%为PMN）的50%的原因。与其他细胞类型相比，PMN在细胞对细胞基础上更有效，致敏细胞毒性所需抗血清更少，且更快、更完全地破坏IBR - GBK细胞，这些发现可能意味着PMN可能是导致疱疹病毒感染早期恢复的最重要细胞类型。
