Anagnostou E, Spengos K, Margeti S, Vassilopoulou S, Paraskevas G P, Zis V
Department of Neurology, Eginition Hospital, University of Athens, Vas. Sophias Avenue 74, 11528 Athens, Greece.
J Neurol Sci. 2009 May 15;280(1-2):118-9. doi: 10.1016/j.jns.2009.02.356. Epub 2009 Mar 6.
Gaze-evoked nystagmus is caused by a "leaky" neural integrator, which fails to maintain eccentric gaze positions after centrifugal eye movements. It is usually observed as the result of toxic, metabolic or paraneoplastic disorders, rather than single structural lesions. We demonstrate a case of an omnidirectional gaze-evoked nystagmus due to an ischemic paramedian ponto-medullar infarction. The most probable explanation is a damage of paramedian tract neurons, which have been recently recognized as a site of neural integration.
凝视诱发性眼球震颤由“泄漏”的神经整合器引起，在离心性眼球运动后，该整合器无法维持偏中心注视位置。它通常是由中毒、代谢或副肿瘤性疾病引起，而非单一结构性病变所致。我们报告一例因桥脑延髓旁正中缺血性梗死导致的全向凝视诱发性眼球震颤病例。最可能的解释是桥脑延髓旁正中束神经元受损，这些神经元最近被认为是神经整合的部位。
