Moro Toru, Kawaguchi Hiroshi, Ishihara Kazuhiko, Kyomoto Masayuki, Karita Tatsuro, Ito Hideya, Nakamura Kozo, Takatori Yoshio
Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Biomaterials. 2009 Jun;30(16):2995-3001. doi: 10.1016/j.biomaterials.2009.02.020. Epub 2009 Mar 9.
Aseptic loosening of artificial hip joints induced by wear particles from the polyethylene (PE) liner remains the ruinous problem limiting their longevity. We reported here that grafting with a polymer, poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC), on the PE liner surface dramatically decreased the wear production under a hip joint simulator condition. We examined that the effect of properties of both PE by cross-linking and femoral head by changing the materials on wearing properties of PE. The PMPC grafting on the liners increased hydrophilicity and decreased friction torque, regardless of the cross-linking of the PE liner or the difference in the femoral head materials. During the hip joint simulator experiments (5 x 10(6) cycles of loading), cross-linking caused a decrease of wear amount and a reduction of the particle size, while the femoral head materials did not affect it. The PMPC grafting abrogated the wear production, confirmed by almost no wear of the liner surface, independently of the liner cross-linking or the femoral head material. We concluded that the PMPC grafting on the PE liner surpasses the liner cross-linking or the change of femoral head materials for extending longevity of artificial hip joints.
由聚乙烯（PE）内衬磨损颗粒引起的人工髋关节无菌性松动仍然是限制其使用寿命的毁灭性问题。我们在此报告，在PE内衬表面接枝聚合物聚（2-甲基丙烯酰氧基乙基磷酰胆碱（MPC））（PMPC），在髋关节模拟器条件下可显著减少磨损产生。我们研究了通过交联改变PE的性能以及通过改变材料改变股骨头对PE磨损性能的影响。内衬上的PMPC接枝增加了亲水性并降低了摩擦扭矩，无论PE内衬的交联情况或股骨头材料的差异如何。在髋关节模拟器实验（5×10^6次加载循环）期间，交联导致磨损量减少和颗粒尺寸减小，而股骨头材料对此没有影响。PMPC接枝消除了磨损产生，这通过内衬表面几乎无磨损得到证实，与内衬交联或股骨头材料无关。我们得出结论，在PE内衬上接枝PMPC在延长人工髋关节使用寿命方面优于内衬交联或改变股骨头材料。
