Park Se Young, Yoo Kyung-Hyeon, Yoon Seog-Young, Son Woo-Sung, Kim Yong-Ii
Department of Orthodontics, Dental Research Institute, Pusan National University, Yangsan 50612, Korea.
School of Materials Science and Engineering, Pusan National University, Busan 46241, Korea.
Nanomaterials (Basel). 2020 Jun 30;10(7):1282. doi: 10.3390/nano10071282.
2-methacryloyloxyethyl phosphorylcholine (MPC) is known to have antibacterial and protein-repellent effects, whereas mesoporous bioactive glass nanoparticles (MBN) are known to have remineralisation effects. We evaluated the antibacterial and remineralisation effects of mixing MPC and MBN at various ratios with orthodontic bonding agents. MPC and MBN were mixed in the following weight percentages in CharmFil-Flow (CF): CF, 3% MPC, 5% MPC, 3% MPC + 3% MBN, and 3% MPC + 5% MBN. As the content of MPC and MBN increased, the mechanical properties of the resin decreased. At 5% MPC, the mechanical properties decreased significantly with respect to CF (shear bond strength), gelation of MPC occurred, and no significant difference was observed in terms of protein adsorption compared to the control group. Composition 3% MPC + 5% MBN exhibited the lowest protein adsorption because the proportion of hydrophobic resin composite decreased; CF (91.8 ± 4.8 μg/mL), 3% MPC (73.9 ± 2.6 μg/mL), 3% MPC + 3% MBN (69.4 ± 3.6 μg/mL), and 3% MPC + 5% MBN (55.9 ± 1.6 μg/mL). In experiments against and , addition of MPC and MBN resulted in significant antibacterial effects. In another experiment, the anti-demineralisation effect was improved when MPC was added, and when MBN was additionally added, it resulted in a synergetic effect. When MPC and MBN were added at an appropriate ratio to the orthodontic bonding agents, the protein-repellent, antibacterial, and anti-demineralisation effects were improved. This combination could thus be an alternative way of treating white spot lesions.
2-甲基丙烯酰氧乙基磷酰胆碱（MPC）具有抗菌和抗蛋白吸附作用，而介孔生物活性玻璃纳米颗粒（MBN）具有再矿化作用。我们评估了将MPC和MBN以不同比例与正畸粘结剂混合后的抗菌和再矿化效果。MPC和MBN在CharmFil-Flow（CF）中按以下重量百分比混合：CF、3%MPC、5%MPC、3%MPC + 3%MBN和3%MPC + 5%MBN。随着MPC和MBN含量的增加，树脂的力学性能下降。在5%MPC时，相对于CF，其力学性能（剪切粘结强度）显著下降，MPC发生凝胶化，与对照组相比，在蛋白吸附方面未观察到显著差异。3%MPC + 5%MBN组合物的蛋白吸附最低，因为疏水性树脂复合材料的比例降低；CF（91.8±4.8μg/mL）、3%MPC（73.9±2.6μg/mL）、3%MPC + 3%MBN（69.4±3.6μg/mL）和3%MPC + 5%MBN（55.9±1.6μg/mL）。在针对[具体菌种1]和[具体菌种2]的实验中，添加MPC和MBN产生了显著的抗菌效果。在另一项实验中，添加MPC时抗脱矿效果得到改善，额外添加MBN时产生协同效应。当以适当比例将MPC和MBN添加到正畸粘结剂中时，抗蛋白吸附、抗菌和抗脱矿效果均得到改善。因此，这种组合可能是治疗白斑病变的一种替代方法。
