在轻度癫痫范例中分析脑电图时线性和非线性同步测量方法的评估
Assessment of linear and nonlinear synchronization measures for analyzing EEG in a mild epileptic paradigm.
作者信息
Sakkalis Vangelis, Doru Giurc Neanu Ciprian, Xanthopoulos Petros, Zervakis Michalis E, Tsiaras Vassilis, Yang Yinghua, Karakonstantaki Eleni, Micheloyannis Sifis
机构信息
Institute of Computer Science, Foundation for Research and Technology, Heraklion 71110, Greece.
出版信息
IEEE Trans Inf Technol Biomed. 2009 Jul;13(4):433-41. doi: 10.1109/TITB.2008.923141. Epub 2008 Apr 11.
Epilepsy is one of the most common brain disorders and may result in brain dysfunction and cognitive disturbances. Epileptic seizures usually begin in childhood without being accommodated by brain damage and are tolerated by drugs that produce no brain dysfunction. In this study, cognitive function is evaluated in children with mild epileptic seizures controlled with common antiepileptic drugs. Under this prism, we propose a concise technical framework of combining and validating both linear and nonlinear methods to efficiently evaluate (in terms of synchronization) neurophysiological activity during a visual cognitive task consisting of fractal pattern observation. We investigate six measures of quantifying synchronous oscillatory activity based on different underlying assumptions. These measures include the coherence computed with the traditional formula and an alternative evaluation of it that relies on autoregressive models, an information theoretic measure known as minimum description length, a robust phase coupling measure known as phase-locking value, a reliable way of assessing generalized synchronization in state-space and an unbiased alternative called synchronization likelihood. Assessment is performed in three stages; initially, the nonlinear methods are validated on coupled nonlinear oscillators under increasing noise interference; second, surrogate data testing is performed to assess the possible nonlinear channel interdependencies of the acquired EEGs by comparing the synchronization indexes under the null hypothesis of stationary, linear dynamics; and finally, synchronization on the actual data is measured. The results on the actual data suggest that there is a significant difference between normal controls and epileptics, mostly apparent in occipital-parietal lobes during fractal observation tests.
癫痫是最常见的脑部疾病之一,可能导致脑功能障碍和认知紊乱。癫痫发作通常始于儿童期,并无脑损伤,且可被不产生脑功能障碍的药物所控制。在本研究中,对使用常见抗癫痫药物控制轻度癫痫发作的儿童的认知功能进行了评估。在此框架下,我们提出了一个简洁的技术框架,将线性和非线性方法相结合并进行验证,以在由分形图案观察组成的视觉认知任务期间有效地评估(从同步角度)神经生理活动。我们基于不同的基本假设研究了六种量化同步振荡活动的指标。这些指标包括用传统公式计算的相干性及其基于自回归模型的替代评估、一种称为最小描述长度的信息论指标、一种称为锁相值的稳健相位耦合指标、一种在状态空间中评估广义同步的可靠方法以及一种称为同步似然性的无偏替代方法。评估分三个阶段进行;首先,在噪声干扰不断增加的情况下,在耦合非线性振荡器上验证非线性方法;其次,通过比较在平稳、线性动力学的零假设下的同步指标,进行替代数据测试以评估所获取脑电图可能存在的非线性通道相互依赖性;最后,测量实际数据上的同步情况。实际数据的结果表明,正常对照组和癫痫患者之间存在显著差异,在分形观察测试期间,这种差异主要在枕顶叶明显。