肉毒杆菌毒素对五肽胃泌素酸分泌作用的修饰。
Modification of the action of pentagastrin on acid secretion by botulinum toxin.
作者信息
Kondo T, Magee D F
出版信息
Experientia. 1977 Jun 15;33(6):750-1. doi: 10.1007/BF01944169.
PMID:19277
Abstract
I.v botulinum toxin after 60-90 min abolished the dose-response relationship between pentagastrin and gastric acid secretion in anesthetized rats and guinea-pigs. The toxin reduced but did not abolish the acid stimulatory effect of histamine. As expected, the acid response to vagal stimulation was abolished and that to methacholine in rats was unaltered by the toxin.
摘要
静脉注射肉毒杆菌毒素60 - 90分钟后，麻醉大鼠和豚鼠体内五肽胃泌素与胃酸分泌之间的剂量反应关系消失。该毒素降低了组胺的酸刺激作用，但并未消除。正如预期的那样，毒素消除了迷走神经刺激引起的酸反应，而大鼠对乙酰甲胆碱的酸反应则未受毒素影响。
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