在清醒大鼠中，甲硫米特对五肽胃泌素和乙酰甲胆碱剂量-反应曲线的置换作用。
Displacement by metiamide of the dose-response curves to pentagastrin and methacholine in the conscious rat.
作者信息
Lundell L
出版信息
Br J Pharmacol. 1975 Aug;54(4):507-9. doi: 10.1111/j.1476-5381.1975.tb07598.x.
Abstract
- The effect of a specific histamine H2-receptor antagonist, metiamide, on the acid dose-response curves for pentagastrin or methacholine was studied in rats provided with Heidenhain pouches. 2. Metiamide induced a shift to the right of the dose-response curve to pentagastrin and lowered the maximal secretion. 3. In contrast, metiamide only increased the ED50 for methacholine but did not alter the calculated maximal response. 4. The effect of metiamide on pentagastrin and methacholine-induced secretion is in agreement with the previously suggested difference in the part played by mucosal histamine in the mode of action of the two stimulatory agents.
摘要
- 在具有海登海因小胃的大鼠中，研究了一种特定的组胺H2受体拮抗剂甲硫米特对五肽胃泌素或乙酰甲胆碱酸剂量反应曲线的影响。2. 甲硫米特使五肽胃泌素的剂量反应曲线向右移动，并降低了最大分泌量。3. 相比之下，甲硫米特仅增加了乙酰甲胆碱的半数有效剂量（ED50），但未改变计算得出的最大反应。4. 甲硫米特对五肽胃泌素和乙酰甲胆碱诱导的分泌的影响与先前提出的黏膜组胺在两种刺激剂作用方式中所起作用的差异一致。
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