用于细胞迁移和顺行流动的网络收缩模型。
Network contraction model for cell translocation and retrograde flow.
作者信息
Verkhovsky A B, Svitkina T M, Borisy G G
机构信息
Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA.
出版信息
Biochem Soc Symp. 1999;65:207-22.
PMID:10320940
Abstract
Kinetic and structural analysis of the actin-myosin II system in mammalian fibroblasts and fish epidermal keratocytes suggests that the cell's motility machinery arises behind the leading edge in the form of myosin filament clusters immersed in an actin filament network. We discuss how the contraction of this actin-myosin II network is related to the formation of actin-myosin filament bundles, cell translocation and retrograde flow.
摘要
对哺乳动物成纤维细胞和鱼类表皮角质形成细胞中肌动蛋白-肌球蛋白II系统的动力学和结构分析表明，细胞的运动机制以肌球蛋白丝簇的形式出现在前沿之后，这些丝簇沉浸在肌动蛋白丝网络中。我们讨论了这个肌动蛋白-肌球蛋白II网络的收缩如何与肌动蛋白-肌球蛋白丝束的形成、细胞移位和逆行流动相关。
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