Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey.
Eur J Pediatr. 2009 Dec;168(12):1541-2. doi: 10.1007/s00431-009-0964-6. Epub 2009 Mar 11.
Nicolau syndrome (NS), also known as livedo-like dermatitis or embolia cutis medicamentosa, is a very rare complication of intramuscular and intraarticular injection of various drugs.
We herein report a case of NS developing approximately 2 h after the intramuscular administration of vitamin K1 in an extremely low birth weight premature newborn. To our knowledge, this patient is the youngest case suffering from such a livedoid skin necrosis and the first case of neonatal NS developing due to intramuscular administration of vitamin K1.
尼科劳综合征（NS），又称类网状皮肤炎或药物性皮肤栓塞，是各种药物肌内和关节内注射的一种非常罕见的并发症。
我们在此报告一例极低出生体重早产儿在肌内注射维生素 K1 后约 2 小时发生 NS 的病例。据我们所知，该患者是患此类类网状皮肤坏死的年龄最小的病例，也是首例因肌内注射维生素 K1 而导致的新生儿 NS 病例。
