Brightman L J, Terezhalmy G T, Greenwell H, Jacobs M, Enlow D H
Department of Orthodontics, Case Western Reserve University, Cleveland, Ohio.
Am J Orthod Dentofacial Orthop. 1991 Oct;100(4):324-9. doi: 10.1016/0889-5406(91)70069-9.
The purpose of this study was to assess the effectiveness of a 0.12% chlorhexidine gluconate (CH) mouthrinse, Peridex, on orthodontic patients 11 through 17 years of age with established gingivitis. Thirty-four subjects were divided into two groups (CH and placebo) of 17 subjects each on the basis of gender, and they were evaluated at baseline, at 6 weeks, and at 12 weeks in a double-blinded manner. The gingival index (GI) of Löe and Silness, the plaque index (PI) of Silness and Löe, the Eastman Interproximal Bleeding Index, and the CWRU staining index were recorded for each subject. The subjects in the CH group, as compared with the placebo group, had statistically significant reductions, expressed as percent reductions against baseline, at the conclusion of this 3-month period: PI = 64.9%, GI = 60.0%, and gingival bleeding = 77.2%. Staining was in the moderate range, and it was concentrated on the mandibular lingual surfaces. Peridex, in combination with mechanical plaque removal, proved to be an important therapeutic agent in controlling gingival inflammation, bleeding, and plaque accumulation in orthodontic patients 11 through 17 years of age with established gingivitis.
本研究的目的是评估0.12%葡萄糖酸氯己定（CH）漱口水（Peridex）对11至17岁患有已确诊牙龈炎的正畸患者的疗效。34名受试者根据性别分为两组，每组17人，以双盲方式在基线、6周和12周时进行评估。记录每名受试者的Löe和Silness牙龈指数（GI）、Silness和Löe菌斑指数（PI）、伊士曼邻面出血指数以及凯斯西储大学染色指数。与安慰剂组相比，CH组的受试者在这3个月结束时，以相对于基线的降低百分比表示，在统计学上有显著降低：PI = 64.9%，GI = 60.0%，牙龈出血 = 77.2%。染色处于中度范围，且集中在下颌舌面。Peridex与机械性菌斑清除相结合，被证明是控制11至17岁患有已确诊牙龈炎的正畸患者牙龈炎症、出血和菌斑积聚的一种重要治疗剂。
