Physiologie de la Nutrition, UMR Inserm U866, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation, Université de Bourgogne, 1, Esplanade Erasme, F-21000 Dijon, France.
Prog Lipid Res. 2009 Mar;48(2):101-15. doi: 10.1016/j.plipres.2009.01.001.
Over the two last decades, cloning of proteins responsible for trafficking and metabolic fate of long-chain fatty acids (LCFA) in gut has provided new insights on cellular and molecular mechanisms involved in fat absorption. To this systematic cloning period, functional genomics has succeeded in providing a new set of surprises. Disruption of several genes, thought to play a crucial role in LCFA absorption, did not lead to clear phenotypes. This observation raises the question of the real physiological role of lipid-binding proteins and lipid-metabolizing enzymes expressed in enterocytes. The goal of this review is to analyze present knowledge concerning the main steps of intestinal fat absorption from LCFA uptake to lipoprotein release and to assess their impact on health.
在过去的二十年中，克隆负责肠道中长链脂肪酸（LCFA）运输和代谢命运的蛋白质，为脂肪吸收涉及的细胞和分子机制提供了新的见解。在这个系统的克隆时期，功能基因组学成功地提供了一系列新的惊喜。破坏了一些被认为在 LCFA 吸收中起关键作用的基因，但并没有导致明显的表型。这一观察结果提出了这样一个问题，即在肠细胞中表达的脂质结合蛋白和脂质代谢酶的真正生理作用是什么。这篇综述的目的是分析目前关于从 LCFA 摄取到脂蛋白释放的肠道脂肪吸收的主要步骤的知识，并评估它们对健康的影响。
