Imazato Satoshi
Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
Dent Mater J. 2009 Jan;28(1):11-9. doi: 10.4012/dmj.28.11.
Restorative materials in the new era should be "bio-active", and antibacterial effects are highlighted as one of the important properties. In order to achieve resin-based restoratives with antibacterial effects, an antibacterial monomer MDPB has been developed. The primer incorporating MDPB demonstrated cavity-disinfecting effects, and the world's first antibacterial adhesive system employing the MDPB-containing primer was successfully commercialized. MDPB is potentially applicable to various restoratives since immobilization of the antibacterial component by polymerization of MDPB enables no deterioration in mechanical properties of cured resins and exhibition of inhibitory effects against bacterial growth on their surfaces. For glass-ionomer cements used for atraumatic restorative treatment, the approach to provide antibacterial activity has been attempted by addition of chlorhexidine. Incorporation of 1% chlorhexidine diacetate was found to be optimal to give appropriate antibacterial and physical properties, being effective to reduce the bacteria in affected and infected dentin in vivo.
新时代的修复材料应具有“生物活性”，抗菌效果被视为重要特性之一。为了制备具有抗菌效果的树脂基修复材料，已研发出一种抗菌单体MDPB。含有MDPB的底漆展现出窝洞消毒效果，并且全球首个采用含MDPB底漆的抗菌粘结系统已成功商业化。MDPB可能适用于各种修复材料，因为通过MDPB聚合固定抗菌成分可使固化树脂的机械性能不降低，并能在其表面展现出对细菌生长的抑制作用。对于用于非创伤性修复治疗的玻璃离子水门汀，已尝试通过添加氯己定来赋予其抗菌活性。发现加入1%的双醋酸氯己定可达到最佳效果，能赋予合适的抗菌性能和物理性能，在体内可有效减少患牙和感染牙本质中的细菌。
