Wehby George L, Murray Jeffrey C, Castilla Eduardo E, Lopez-Camelo Jorge S, Ohsfeldt Robert L
Dept of Health Management and Policy, University of Iowa, E204, GH, Iowa City, IA 52242, USA.
Health Policy Plan. 2009 May;24(3):175-88. doi: 10.1093/heapol/czp005. Epub 2009 Mar 12.
The impact of prenatal care use on birth outcomes has been understudied in South American countries. This study assessed the effects of various measures of prenatal care use on birth weight (BW) and gestational age outcomes using samples of infants born without and with common birth defects from Brazil, and evaluated the demand for prenatal care. Prenatal visits improved BW in the group without birth defects through increasing both fetal growth rate and gestational age, but prenatal care visits had an insignificant effect on BW in the group with birth defects when adjusting for gestational age. Prenatal care delay had no effects on BW in both infant groups but increased preterm birth risk in the group without birth defects. Inadequate care versus intermediate care also increased LBW risk in the group without birth effects. Quantile regression analyses revealed that prenatal care visits had larger effects at low compared with high BW quantiles. Several other prenatal factors and covariates such as multivitamin use and number of previous live births had significant effects on the studied outcomes. The number of prenatal care visits was significantly affected by several maternal health and fertility indicators. Significant geographic differences in utilization were observed as well. The study suggests that more frequent use of prenatal care can increase BW significantly in Brazil, especially among pregnancies that are uncomplicated with birth defects but that are at high risk for low birth weight. Further research is needed to understand the effects of prenatal care use for pregnancies that are complicated with birth defects.
在南美国家,产前保健的使用对出生结局的影响尚未得到充分研究。本研究使用来自巴西的无出生缺陷和有常见出生缺陷婴儿的样本,评估了产前保健使用的各种指标对出生体重(BW)和胎龄结局的影响,并评估了产前保健的需求。产前检查通过提高胎儿生长速度和胎龄,改善了无出生缺陷组的出生体重,但在调整胎龄后,产前检查对有出生缺陷组的出生体重影响不显著。产前保健延迟对两组婴儿的出生体重均无影响,但增加了无出生缺陷组的早产风险。与中级保健相比,不足的保健也增加了无出生影响组的低出生体重风险。分位数回归分析显示,与高出生体重分位数相比,产前检查在低出生体重分位数时的影响更大。其他一些产前因素和协变量,如多种维生素的使用和既往活产次数,对研究结局有显著影响。产前检查次数受到几个孕产妇健康和生育指标的显著影响。在利用方面也观察到显著的地理差异。该研究表明,在巴西,更频繁地使用产前保健可以显著增加出生体重,特别是在无出生缺陷但低出生体重风险高的妊娠中。需要进一步研究以了解产前保健对有出生缺陷的妊娠的影响。