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阿根廷按出生缺陷状况划分的产前护理需求及其对出生结局的影响。

Prenatal care demand and its effects on birth outcomes by birth defect status in Argentina.

作者信息

Wehby George L, Murray Jeffrey C, Castilla Eduardo E, Lopez-Camelo Jorge S, Ohsfeldt Robert L

机构信息

Department of Health Management and Policy, College of Public Health, University of Iowa, E204, GH, Iowa City, IA 52242, USA.

出版信息

Econ Hum Biol. 2009 Mar;7(1):84-95. doi: 10.1016/j.ehb.2008.10.001. Epub 2008 Oct 30.

Abstract

Our objective was to identify determinants of prenatal care demand and evaluate the effects of this demand on low birth weight and preterm birth. Delay in initiating prenatal care was modeled as a function of pregnancy risk indicators, enabling factors, and regional characteristics. Conditional maximum likelihood (CML) estimation was used to model self-selection into prenatal care use when estimating its effectiveness. Birth registry data was collected post delivery on infants with and without common birth defects born in 1995-2002 in Argentina using a standard procedure. Several maternal health and fertility indicators had significant effects on prenatal care use. In the group without birth defects, prenatal care delay increased significantly LBW and preterm birth when accounting for self-selection using the CML model but not in the standard probit model. Prenatal care was found to be ineffective on average in the birth defect group. The self-selection of higher risk women into earlier initiation of prenatal care resulted in underestimation of prenatal care effectiveness when using a standard probit model with several covariates. Large improvements in birth outcomes are suggested with earlier initiation of prenatal care for pregnancies uncomplicated with birth defects in Argentina, implying large opportunity costs from the long waiting time observed in this sample (about 17 weeks on average). The suggested ineffectiveness for pregnancies complicated with common birth defects deserves further research.

摘要

我们的目标是确定产前护理需求的决定因素,并评估这种需求对低出生体重和早产的影响。将开始产前护理的延迟建模为妊娠风险指标、促成因素和区域特征的函数。在估计产前护理的有效性时,使用条件最大似然(CML)估计对自我选择使用产前护理进行建模。采用标准程序收集了1995 - 2002年在阿根廷出生的有和没有常见出生缺陷的婴儿的出生登记数据。几个孕产妇健康和生育指标对产前护理的使用有显著影响。在无出生缺陷组中,使用CML模型考虑自我选择时,产前护理延迟会显著增加低出生体重和早产的发生率,但在标准概率模型中则不然。在出生缺陷组中,产前护理平均被发现无效。当使用带有几个协变量的标准概率模型时,高风险女性自我选择更早开始产前护理导致对产前护理有效性的低估。对于阿根廷无出生缺陷的妊娠,更早开始产前护理表明出生结局会有很大改善,这意味着在该样本中观察到的长时间等待(平均约17周)会带来巨大的机会成本。对于伴有常见出生缺陷的妊娠所表明的无效性值得进一步研究。

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