Willers S, Svenonius E, Skarping G
Department of Occupational and Environmental Medicine, Lund University, General Hospital, Malmö, Sweden.
Allergy. 1991 Jul;46(5):330-4. doi: 10.1111/j.1398-9995.1991.tb00595.x.
Passive exposure to tobacco smoke was assessed in children with asthma (age 3-15) and in referents. There was statistically significantly (P less than 0.0005) higher excretion of the nicotine metabolite, cotinine, in the urine of 49 children with asthma (geometric mean 10 ng/ml) compared with 77 referents (4.8 ng/ml). Maternal smoking was statistically significantly more prevalent among the asthmatics than among the referents (relative risk = RR = 2.6, 95% C1 = 1.2-5.3). In conclusion, the exposure to environmental tobacco smoke in asthmatic children was higher than among healthy children, indicating that passive smoking may be a predisposing and/or aggravating factor for childhood asthma.
对患有哮喘的儿童（3至15岁）及其对照对象进行了被动接触烟草烟雾情况的评估。49名哮喘儿童尿液中的尼古丁代谢物可替宁排泄量（几何平均数为10纳克/毫升）在统计学上显著高于77名对照对象（4.8纳克/毫升）（P小于0.0005）。哮喘患者中母亲吸烟在统计学上显著比对照对象更普遍（相对危险度=RR=2.6，95%可信区间=1.2 - 5.3）。总之，哮喘儿童接触环境烟草烟雾的情况高于健康儿童，表明被动吸烟可能是儿童哮喘的一个诱发和/或加重因素。
