Sanchez-Carpintero Rocio, Albesa Sergio Aguilera, Crespo Nerea, Villoslada Pablo, Narbona Juan
Pediatric Neurology Unit, Department of Paediatrics, University Hospital, University of Navarra, 31080 Pamplona, Spain.
J Neurol. 2009 Jul;256(7):1103-8. doi: 10.1007/s00415-009-5076-8. Epub 2009 Mar 14.
Attention deficit/hyperactivity disorder (ADHD) is often present in patients with post-streptococcal neuropsychiatric disorders such as Sydenham's chorea and PANDAS, in which anti-basal ganglia antibodies (ABGA) have been frequently found. Our study investigates the hypothesis that pharyngeal group A beta-hemolytic streptococcus (GABHS) infections and serum ABGA are more frequent in children with ADHD non-comorbid (nc-ADHD) with obsessive-compulsive disorder or tics than in controls. We compared 22 children with nc-ADHD (DSM-IV-TR) and 22 healthy controls matched by age, gender and season of sample collection, for the frequency of recent GABHS infection and the presence of ABGA. Eleven out of 22 children (51%) with nc-ADHD showed evidence of GABHS infection compared to three out of 22 (14%) controls (P = 0.007). We found positive ABGA in one ADHD subject (4%) and in one control (4%). This preliminary study indicates that frequency of ABGA in children with nc-ADHD does not differ from that in matched controls, despite the fact that our ADHD patients had had more recent GABHS infections than the controls. This suggests that ABGA do not have a role in the pathogenesis of nc-ADHD.
注意力缺陷/多动障碍（ADHD）常出现在患有链球菌感染后神经精神障碍的患者中，如 Sydenham 舞蹈病和儿科自身免疫性神经精神障碍相关链球菌感染（PANDAS），在这些疾病中经常发现抗基底神经节抗体（ABGA）。我们的研究调查了这样一个假设：与对照组相比，患有强迫症或抽动症的非共病 ADHD（nc-ADHD）儿童中，咽部 A 组β溶血性链球菌（GABHS）感染和血清 ABGA 更为常见。我们比较了 22 名患有 nc-ADHD（DSM-IV-TR）的儿童和 22 名按年龄、性别和样本采集季节匹配的健康对照，以了解近期 GABHS 感染的频率和 ABGA 的存在情况。22 名患有 nc-ADHD 的儿童中有 11 名（51%）显示有 GABHS 感染证据，而 22 名对照中有 3 名（14%）（P = 0.007）。我们在一名 ADHD 受试者（4%）和一名对照（4%）中发现 ABGA 呈阳性。这项初步研究表明，nc-ADHD 儿童中 ABGA 的频率与匹配对照组没有差异，尽管我们的 ADHD 患者近期 GABHS 感染比对照组更多。这表明 ABGA 在 nc-ADHD 的发病机制中不起作用。
