非共病注意缺陷多动障碍中的抗基底神经节抗体和抗链球菌溶血素O
Antibasal Ganglia Antibodies and Antistreptolysin O in Noncomorbid ADHD.
作者信息
Toto Maddalena, Margari Francesco, Simone Marta, Craig Francesco, Petruzzelli Maria Giuseppina, Tafuri Silvio, Margari Lucia
机构信息
University of "Aldo Moro" Bari, Italy.
University of "Aldo Moro" Bari, Italy
出版信息
J Atten Disord. 2015 Nov;19(11):965-70. doi: 10.1177/1087054712455505. Epub 2012 Sep 5.
OBJECTIVE
An association between streptococcal infections, ABGA positivity, and no comorbidity ADHD (nc-ADHD) has been little investigated. The aim of this study was to evaluate the streptococcal infection frequency, defined entitled serum antistreptolysin O (ASO), and frequency of serum ABGA positivity in a sample of patients with nc-ADHD.
METHOD
In all 40 participants were investigated the ASO titer and ABGA.
RESULTS
The results showed that ABGA positivity was statistically significantly higher in patients affected by ADHD than in patients of a control group, and pathological values of ASO were statistically more frequent in the ADHD group than the control group.
CONCLUSION
These data suggest that streptococcal infections and autoimmune reactions against the basal ganglia are more frequent in ADHD patients than patients in a control group.
目的
链球菌感染、抗基底节抗体（ABGA）阳性与无共病注意缺陷多动障碍（nc-ADHD）之间的关联鲜有研究。本研究旨在评估nc-ADHD患者样本中链球菌感染频率（定义为血清抗链球菌溶血素O（ASO））及血清ABGA阳性频率。
方法
对40名参与者均进行了ASO滴度和ABGA检测。
结果
结果显示，ADHD患者的ABGA阳性率在统计学上显著高于对照组患者，且ADHD组ASO的病理值在统计学上比对照组更常见。
结论
这些数据表明，ADHD患者比对照组患者更易发生链球菌感染和针对基底节的自身免疫反应。
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