预防性应用局部制剂减少妊娠纹。一项双盲试验。

Prophylaxis of Striae gravidarum with a topical formulation. A double blind trial.

机构信息

School of Medicine, Unit of Pharmacology, University of Barcelona, REUS (Tarragona), Spain.

出版信息

Int J Cosmet Sci. 1991 Feb;13(1):51-7. doi: 10.1111/j.1467-2494.1991.tb00547.x.

DOI:10.1111/j.1467-2494.1991.tb00547.x

PMID:19291041

Abstract

Synopsis A prophylactic antistriae cream (Centella asiatica extract, alpha-tocopherol, and collagen-elastin hydrolisates) was assessed by a double blind trial in 80 pregnant women. In the placebo group 22 women (56%) presented striae, whereas in the treated group only 14 women (34%) developed striae in this pregnancy; this difference was significant (p < 0.05; chi(2) test). An arbitrary score was designed to assess the intensity of striae (from 0 to 3); this score was 1.42 (sd 0.5) in the treated group and 2.13 (sd 1.32) in the placebo group and this difference was also significant (p= 0.014; Mann-Whitney test). In women with a history of striae during puberty, the active cream induced a significant absolute prevention in 89% of the cases whereas in the placebo group all the women developed striae (p= 0.00014; chi(2) test).

摘要

概要

一项双盲试验评估了一种预防性防妊娠纹霜（积雪草提取物、α-生育酚和胶原弹性水解物）在 80 名孕妇中的效果。在安慰剂组中，有 22 名妇女（56%）出现了妊娠纹，而在治疗组中，只有 14 名妇女（34%）在此次妊娠中出现了妊娠纹；这一差异具有统计学意义（p<0.05；卡方检验）。研究设计了一个任意评分来评估妊娠纹的严重程度（从 0 到 3）；治疗组的评分为 1.42（标准差 0.5），安慰剂组的评分为 2.13（标准差 1.32），这一差异也具有统计学意义（p=0.014；曼-惠特尼检验）。在青春期有妊娠纹史的女性中，活性乳膏在 89%的情况下显著预防了妊娠纹的发生，而在安慰剂组中所有女性都出现了妊娠纹（p=0.00014；卡方检验）。