SCH39304与氟康唑在播散性球孢子菌病小鼠模型中的疗效
Efficacy of SCH39304 and fluconazole in a murine model of disseminated coccidioidomycosis.
作者信息
Clemons K V, Hanson L H, Perlman A M, Stevens D A
机构信息
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
出版信息
Antimicrob Agents Chemother. 1990 May;34(5):928-30. doi: 10.1128/AAC.34.5.928.
Abstract
The efficacies of SCH39304 (SCH) and fluconazole (FLU) were tested in a murine model of coccidioidomycosis. CD-1 mice were infected with Coccidioides immitis and dosed with SCH at 2, 10, 25, or 50 mg/kg per day or FLU at 10 or 100 mg/kg per day. Survival was enhanced (P less than 0.001) by both drugs at all doses. Residual burdens of C. immitis in the organs of mice treated with SCH at 25 or 50 mg/kg per day were lower than in mice treated with FLU at 100 mg/kg per day (P less than 0.001). These results indicate that SCH is an effective therapy for coccidioidomycosis and is superior to FLU in this comparison.
摘要
在球孢子菌病的小鼠模型中测试了SCH39304（SCH）和氟康唑（FLU）的疗效。将CD-1小鼠感染球孢子菌，并分别以每天2、10、25或50mg/kg的剂量给予SCH，或以每天10或100mg/kg的剂量给予FLU。所有剂量的两种药物均能提高生存率（P<0.001）。每天给予25或50mg/kg SCH治疗的小鼠器官中球孢子菌的残留负担低于每天给予100mg/kg FLU治疗的小鼠（P<0.001）。这些结果表明，SCH是治疗球孢子菌病的有效疗法，在该比较中优于FLU。
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