Sch 39304、氟康唑和两性霉素B对荚膜组织胞浆菌的体外及体内活性
In vitro and in vivo activities of Sch 39304, fluconazole, and amphotericin B against Histoplasma capsulatum.
作者信息
Kobayashi G S, Travis S J, Rinaldi M G, Medoff G
机构信息
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
Antimicrob Agents Chemother. 1990 Apr;34(4):524-8. doi: 10.1128/AAC.34.4.524.
Abstract
The antifungal activities of amphotericin B and two triazoles, Sch 39304 and fluconazole, were tested against Histoplasma capsulatum. In this study Sch 39304 compared favorably with amphotericin B in treating histoplasmosis in normal and leukopenic mice, whereas fluconazole was much less active. The differences in the efficacies of the triazoles appeared to be due to differences in their pharmacokinetics and the dosage schedule that was used. For amphotericin B there was a good correlation between in vitro and in vivo efficacy, but this was not true of the triazole derivatives. These results further demonstrate that, with the methods used in this study, in vitro susceptibility testing of triazoles may not be predictive of in vivo activity against isolates of H. capsulatum.
摘要
两性霉素B以及两种三唑类药物（Sch 39304和氟康唑）针对荚膜组织胞浆菌的抗真菌活性进行了测试。在本研究中，在治疗正常小鼠和白细胞减少小鼠的组织胞浆菌病方面，Sch 39304与两性霉素B相比效果良好，而氟康唑的活性则低得多。三唑类药物疗效的差异似乎是由于它们的药代动力学以及所采用的给药方案不同所致。对于两性霉素B，体外和体内疗效之间存在良好的相关性，但三唑衍生物并非如此。这些结果进一步证明，采用本研究中的方法，三唑类药物的体外药敏试验可能无法预测其对荚膜组织胞浆菌分离株的体内活性。
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