De Bruin Marie L, Van Dulmen-den Broeder Eline, Van den Berg Marleen H, Lambalk Cornelis B
Endocr Dev. 2009;15:135-158. doi: 10.1159/000207613. Epub 2009 Mar 3.
Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly enlarging group of childhood cancer survivors. There is much concern, however, about the effects of treatment on reproductive potential. In women there is evidence that both chemotherapy and radiotherapy may have an adverse effect on ovarian function, ovarian reserve and uterine function, clinically leading to sub-fertility, infertility, premature menopause and/or adverse pregnancy outcomes. Here we will first address normal female fertility and methods to detect decreased fertility. Hence we will focus on direct effects as well as late fertility-related adverse effects caused by chemotherapy and radiotherapy, and we will conclude with a summary of current options for fertility preservation in female childhood cancer survivors.
在过去几十年中，儿童癌症治疗取得的进展显著提高了生存率，使得儿童癌症幸存者群体迅速扩大。然而，人们非常关注治疗对生殖潜能的影响。在女性中，有证据表明化疗和放疗可能对卵巢功能、卵巢储备和子宫功能产生不利影响，临床上会导致生育力下降、不孕、过早绝经和/或不良妊娠结局。在此，我们首先将探讨正常女性的生育能力以及检测生育力下降的方法。接下来，我们将重点关注化疗和放疗所造成的直接影响以及与生育力相关的晚期不良影响，最后我们将总结目前针对女性儿童癌症幸存者保留生育力的选择。
