Clark Sally A, Quod M J, Clark M A, Martin D T, Saunders P U, Gore C J
Department of Physiology, Australian Institute of Sport, PO Box 176, Belconnen, ACT, 2616, Australia.
Eur J Appl Physiol. 2009 Jun;106(3):399-406. doi: 10.1007/s00421-009-1027-4. Epub 2009 Mar 18.
The aim of this study was to determine the time course of changes in haemoglobin mass (Hb(mass)) in well-trained cyclists in response to live high:train low (LHTL). Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ~14 h/day. Prior to LHTL duplicate baseline measurements were made of Hb(mass), maximal oxygen consumption (VO(2max)) and serum erythropoietin (sEPO). Hb(mass) was measured weekly during LHTL and twice in the week thereafter. There was a 3.3% increase in Hb(mass) and no change in VO(2max) after LHTL. The mean Hb(mass) increased at a rate of ~1% per week and this was maintained in the week after cessation of LHTL. The sEPO concentration peaked after two nights of LHTL but there was only a trivial correlation (r = 0.04, P = 0.89) between the increase in sEPO and the increase in Hb(mass). Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia.
本研究的目的是确定训练有素的自行车运动员在进行高住低练（LHTL）时血红蛋白总量（Hb(mass)）的变化时间进程。12名训练有素的男性自行车运动员参与了一项为期3周的LHTL方案，其中包括每天约14小时处于3000米模拟海拔高度。在进行LHTL之前，对Hb(mass)、最大摄氧量（VO(2max)）和血清促红细胞生成素（sEPO）进行了两次重复的基线测量。在LHTL期间每周测量Hb(mass)，之后一周测量两次。LHTL后Hb(mass)增加了3.3%，VO(2max)没有变化。平均Hb(mass)每周以约1%的速率增加，并且在LHTL停止后的一周内保持这一增幅。sEPO浓度在LHTL两个晚上后达到峰值，但sEPO的增加与Hb(mass)的增加之间仅有微弱的相关性（r = 0.04，P = 0.89）。试图从中等海拔高度获得促红细胞生成益处的运动员每天需要在低氧环境中度过超过12小时。
