Doege K, Bates A T, White T P, Das D, Boks M P, Liddle P F
Division of Psychiatry, School of Community Health Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Psychophysiology. 2009 May;46(3):566-77. doi: 10.1111/j.1469-8986.2009.00785.x. Epub 2009 Mar 4.
This study examines EEG low frequency characteristics which have been linked to specific cognitive functions such as stimulus encoding and attention during an auditory oddball task in schizophrenia patients and healthy controls. EEG data was recorded from 17 young schizophrenia patients in a stable phase of their illness and 17 healthy controls performing an auditory oddball task. Evoked and induced delta and theta activity, N100, P300 amplitude were computed. Between 200-500 ms after a stimulus was presented, patients displayed significantly reduced P300, less evoked and induced delta and theta activity than controls. We conclude that the well known finding of P300 reduction in schizophrenia can be linked to reductions in delta and theta activity, which are a manifestation of impaired stimulus evaluation, memory retrieval, and a lack of sustained attention.
本研究考察了精神分裂症患者和健康对照在听觉Oddball任务中与特定认知功能（如刺激编码和注意力）相关的脑电图低频特征。记录了17名处于疾病稳定期的年轻精神分裂症患者和17名进行听觉Oddball任务的健康对照的脑电图数据。计算了诱发和诱导的δ波和θ波活动、N100、P300波幅。在呈现刺激后200 - 500毫秒之间，患者的P300波幅显著降低，诱发和诱导的δ波和θ波活动比对照组少。我们得出结论，精神分裂症中P300降低这一众所周知的发现可能与δ波和θ波活动的减少有关，而这是刺激评估受损、记忆检索受损以及缺乏持续注意力的一种表现。
