Kim Jung Young, Park Hyun, Lee Jong Chan, Kim Kyeong Min, Lee Kyo Chul, Ha Hyun Joon, Choi Tae Hyun, An Gwang Il, Cheon Gi Jeong
Molecular Imaging Research Center, Korea Institue of Radiological and Medical Sciences, 215-4 Gongneung-dong, Nowon-gu, Seoul 139-706, Republic of Korea.
Appl Radiat Isot. 2009 Jul-Aug;67(7-8):1190-4. doi: 10.1016/j.apradiso.2009.02.060. Epub 2009 Feb 23.
One of the positron emission radionuclides, (64)Cu, has been reported to be a particularly effective radioisotope in PET imaging study. This utility of (64)Cu depends on the chemical stability in water with proper energy and half-life as gamma-emitters. Hence, we tried to develop a simple method for producing this isotope using an old cyclotron model in our site (50MeV, Scantronics co.). In particular, we designed the equipments of enrich (64)Ni plating system and radioactive (64)Cu separation using plastic cartridge column; (64)Ni plating system on gold foil which located in the 13 degrees angle target toward beam irradiation. For the nuclear reaction of (64)Cu, it was applied to (64)Ni(p, n) (64)Cu at low energy under the degrader composed of Al and Ta foils. After beam irradiation, (64)Cu was identified by multichannel analyzer installed for a HPGe detector and its utility was certified by the microPET images of (64)Cu-ATSM (CT-26 tumor bearing mouse as reported previously). The image quality of (64)Cu was also very similar to that of (18)F radioisotope in microPET scanner. In conclusion, a method of (64)Cu production and its application was successfully established in old cyclotron having high energy.
正电子发射放射性核素之一的（64）Cu，据报道在PET成像研究中是一种特别有效的放射性同位素。（64）Cu的这种用途取决于其在水中的化学稳定性、合适的能量以及作为γ射线发射体的半衰期。因此，我们尝试利用我们场所的一台旧回旋加速器模型（50MeV，Scantronics公司）开发一种生产这种同位素的简单方法。具体而言，我们设计了富集（64）Ni电镀系统的设备以及使用塑料柱盒进行放射性（64）Cu分离的设备；在朝着束流照射呈13度角的靶上的金箔上的（64）Ni电镀系统。对于（64）Cu的核反应，在由铝箔和钽箔组成的降解器下，在低能量条件下将其应用于（64）Ni（p，n）（64）Cu反应。束流照射后，通过为HPGe探测器安装的多道分析仪鉴定（64）Cu，并通过（64）Cu - ATSM的微型PET图像（如先前报道的CT - 26荷瘤小鼠）证明其效用。在微型PET扫描仪中，（64）Cu的图像质量也与（18）F放射性同位素的图像质量非常相似。总之，在高能旧回旋加速器中成功建立了一种（64）Cu的生产方法及其应用。
