Division of Neuroimmunology, Department of Neurology, Wayne State University School of Medicine, Detroit, MI, USA.
Neuropsychiatr Dis Treat. 2007 Apr;3(2):259-67. doi: 10.2147/nedt.2007.3.2.259.
Glatiramer acetate is an immunomodulating drug used in the treatment of multiple sclerosis. It consists of a copolymer of amino acid residues in the same stoichiometric proportions as in myelin basic protein. Its mechanism of action is not entirely known and is probably multifaceted, with deletion of some immune cell populations and stimulation of others in these patients. Some mechanisms involve neuroprotectant effects. There is ample evidence of its efficacy in relapsing-remitting disease, using both clinical and imaging measures of disease activity, and in this paper we review the clinical and basic studies of this drug. Finally we discuss how some of its neuroprotectant effects may be useful in neurodegeneration such as is seen in more advanced cases of multiple sclerosis and other diseases such as amyotrophic lateral sclerosis and Parkinson's disease.
醋酸格拉替雷是一种免疫调节药物，用于治疗多发性硬化症。它由与髓鞘碱性蛋白相同化学计量比例的氨基酸残基组成的共聚物。其作用机制尚不完全清楚，可能具有多方面的作用，包括在这些患者中删除一些免疫细胞群体和刺激其他细胞群体。一些机制涉及神经保护作用。有充分的证据表明，它在复发缓解型疾病中的疗效，使用临床和影像学疾病活动的测量，在本文中，我们回顾了这种药物的临床和基础研究。最后，我们讨论了其一些神经保护作用如何在神经退行性变中有用，如在多发性硬化症和其他疾病如肌萎缩侧索硬化症和帕金森病等更严重的病例中所见。
