Eberlein Jean, Herdt Lukas, Malchow Julian, Rittershaus Annegret, Baumeister Stefan, Helker Christian Sm
Cell Signaling and Dynamics, Faculty of Biology, Philipps-University Marburg, 35043 Marburg, Germany.
Life (Basel). 2021 Oct 15;11(10):1088. doi: 10.3390/life11101088.
The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide. However, we are just beginning to understand which signaling pathways guide blood vessel growth in different tissues and organs. The advantages of the model organism zebrafish () helped to identify novel cellular and molecular mechanisms of vascular growth. In this review we will discuss the current knowledge of vasculogenesis and angiogenesis in the zebrafish embryo. In particular, we describe the molecular mechanisms that contribute to the formation of blood vessels in different vascular beds within the embryo.
功能性心血管系统的建立对所有脊椎动物的发育至关重要。心血管系统发育缺陷会导致心血管疾病，而心血管疾病是全球十大死因之一。然而，我们才刚刚开始了解哪些信号通路指导不同组织和器官中的血管生长。模式生物斑马鱼的优势有助于确定血管生长的新细胞和分子机制。在这篇综述中，我们将讨论斑马鱼胚胎中血管发生和血管生成的现有知识。特别是，我们描述了促成胚胎内不同血管床中血管形成的分子机制。
