Sato Atsushi, Sakurada Kaori, Kuge Atsushi, Ito Miiko, Akasaka Masahiro, Kayama Takamasa
Department of Neurosurgery, Yamagata University Faculty of Medicine, Yamagata 990-9585, Japan.
No Shinkei Geka. 2009 Mar;37(3):277-82.
Here we report a case in which an intracranial germinoma displayed spontaneous regression. An 11-year-old boy presented with polyuria and headache. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed tumors in the suprasellar and pineal regions, and obstructive hydrocephalus. As repeat MRI demonstrated shrinkage of these tumors, resection was deferred. The patient was discharged and followed up with serial MRI. The tumor continued to regress for three weeks; however, the patient was readmitted due to tumor regrowth. We performed endoscopic biopsy, and histopathologic diagnosis was germinoma. The patient underwent three courses of combined chemotherapy and radiotherapy, and complete response was achieved. Although the precise cause of the transient regression is unknown, racranial germinoma may occasionally unde rgo spontane ous regression.
在此，我们报告一例颅内生殖细胞瘤出现自发消退的病例。一名11岁男孩出现多尿和头痛症状。计算机断层扫描（CT）和磁共振成像（MRI）显示鞍上和松果体区有肿瘤，以及梗阻性脑积水。由于重复MRI显示这些肿瘤缩小，手术切除被推迟。患者出院并通过系列MRI进行随访。肿瘤持续消退了三周；然而，患者因肿瘤复发再次入院。我们进行了内镜活检，组织病理学诊断为生殖细胞瘤。患者接受了三个疗程的联合化疗和放疗，并实现了完全缓解。虽然短暂消退的确切原因尚不清楚，但颅内生殖细胞瘤偶尔可能会自发消退。
