Cassano P, Latorre F
Istituto Policattedra di Otorinolaringoiatria, Università di Bari.
Boll Soc Ital Biol Sper. 1991 Mar;67(3):311-8.
Hyperosmolar solutions have recently been introduced as test-substances in the nasal provocation of vasomotor rhinitis subjects. In order to establish a norm, the test was carried out in 40 subjects without nasal pathologies, stimulating with solutions at increasing level of concentrations of NaCl (0.9% - 1.8 - 3.6% - 5.4% - 7.2% - 9%). In all subjects an increase in nasal secretion was verified in proportion to the concentration of the solutions and this increase was statistically significative, with respect to the base, from the concentration 3.6% (p less than 0.001) on words. The statistical analysis has not, however, evidenced any significant differences in secretion between male or female subjects. As far as the variation of nasal resistance is concerned, the rhinomanometric registration has revealed that the hypertonic solutions modify such resistances in a rather casual, absolutely irregular and unimportant way. These results lead to believe that the test is extremely useful in the study of the secretion component of vasomotor rhinopathy.
高渗溶液最近被用作血管运动性鼻炎患者鼻腔激发试验的测试物质。为了建立一个标准，对40名无鼻腔疾病的受试者进行了测试，用浓度不断增加的氯化钠溶液（0.9% - 1.8% - 3.6% - 5.4% - 7.2% - 9%）进行刺激。在所有受试者中，鼻腔分泌物的增加与溶液浓度成正比，并且从浓度3.6%起，相对于基线而言，这种增加具有统计学意义（p小于0.001）。然而，统计分析并未显示男性或女性受试者在分泌物方面有任何显著差异。就鼻腔阻力的变化而言，鼻阻力测量记录显示高渗溶液以一种相当偶然、绝对不规则且不重要的方式改变这种阻力。这些结果使人相信该测试在血管运动性鼻病分泌成分的研究中极其有用。
