儿童期的抗生素与过敏性疾病
Antibiotics and allergic disorders in childhood.
作者信息
Jordan Sue, Storey Mel, Morgan Gareth
机构信息
School of Health Science, Swansea University, Swansea, SA2 8PP, UK.
出版信息
Open Nurs J. 2008;2:48-57. doi: 10.2174/1874434600802010048. Epub 2008 May 22.
AIM
This paper explores the possible association between antibiotics prescribed in infancy and allergic disorders, mainly eczema and asthma, in childhood.
BACKGROUND
No-one fully understands why childhood asthma and eczema have become so common. Some authorities suggest that there may be an association between eczema and asthma and antibiotics prescribed in childhood; however, others disagree. METHOD/EVALUATION: The available literature was reviewed to examine the links between prescribed antibiotics and childhood eczema and asthma. FINDINGS/KEY ISSUE: Some, but not all, research indicates that antibiotic administration in pregnancy, childbirth or infancy may be linked to childhood asthma and eczema, but much uncertainty remains. None of the papers identified stated the doses of antibiotics prescribed. In addition, we were unable to locate studies reporting the interactions between antibiotics and the developing immune system.
CONCLUSION
Health care professionals should be selective when prescribing antibiotics. Further prospective work is needed to guide the prescribing of antibiotics in childbirth and infancy.
目的
本文探讨婴儿期使用抗生素与儿童期过敏性疾病（主要是湿疹和哮喘）之间可能存在的关联。
背景
没有人完全理解为何儿童哮喘和湿疹变得如此普遍。一些权威人士认为湿疹和哮喘与儿童期使用抗生素之间可能存在关联；然而，其他人则持不同意见。方法/评估：回顾现有文献以研究使用抗生素与儿童湿疹和哮喘之间的联系。研究结果/关键问题：一些（但并非全部）研究表明，孕期、分娩期或婴儿期使用抗生素可能与儿童哮喘和湿疹有关，但仍存在很多不确定性。已识别的论文均未说明所使用抗生素的剂量。此外，我们未能找到报告抗生素与发育中的免疫系统之间相互作用的研究。
结论
医疗保健专业人员在开具抗生素处方时应有所选择。需要进一步开展前瞻性研究，以指导分娩期和婴儿期抗生素的使用。
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