Mouridsen S E, Hauschild K-M
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark.
Child Care Health Dev. 2009 Sep;35(5):691-7. doi: 10.1111/j.1365-2214.2009.00954.x. Epub 2009 Mar 23.
A number of studies have shown that the diagnosis of developmental language disorder (DLD) can be unstable over time, such that young children with a diagnosis of DLD may show symptoms more characteristics of autism spectrum disorder (ASD) at a later date.
To estimate the types and prevalence of ASD 469 individuals with a DLD, consecutively assessed in the same clinic during a period of 10 years, and 2345 controls from the general population were screened for ASD through the nationwide Danish Psychiatric Central Register (DPCR). The mean length of observation was 34.7 years, and the mean age at follow-up 35.8 (range: 28.3-46.7) years.
At follow-up, 10 (2.1%) in the DLD group and two (0.09%) in the comparison group were known in the DPCR with a diagnosis of any ASD (P < 0.0001; odds ratio = 25.5; 95% confidence interval 5.5-116.9).
Our results provide additional support to the notion that DLD is a marker of increased vulnerability to the development of ASD.
多项研究表明，发育性语言障碍（DLD）的诊断可能随时间不稳定，以至于患有DLD诊断的幼儿在日后可能表现出更具自闭症谱系障碍（ASD）特征的症状。
为了评估ASD的类型和患病率，对在10年期间于同一诊所连续评估的469名患有DLD的个体以及来自普通人群的2345名对照通过丹麦全国精神病学中央登记处（DPCR）进行了ASD筛查。观察的平均时长为34.7年，随访时的平均年龄为35.8岁（范围：28.3 - 46.7岁）。
在随访时，DLD组中有10人（2.1%），而对照组中有2人（0.09%）被确诊患有任何类型的ASD（P < 0.0001；优势比 = 25.5；95%置信区间5.5 - 116.9）。
我们的结果为DLD是ASD发生易感性增加的一个标志这一观点提供了额外支持。
