Mouridsen Svend Erik, Hauschild Karen-Marie
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark.
Folia Phoniatr Logop. 2011;63(4):195-200. doi: 10.1159/000316413. Epub 2010 Oct 12.
To study the prevalence and types of substance use disorders (SUDs) in adults diagnosed during childhood as having a developmental language disorder (DLD).
The prevalence rates and types of SUDs in a clinical sample of 469 individuals diagnosed during childhood as having a DLD were compared with SUDs in 2,345 matched controls from the general population without a known history of DLD using data from the nationwide Danish Psychiatric Central Register (DPCR). The average observation time was 34.7 years, and the mean age at follow-up was 35.8 years.
Of the 469 individuals with DLD, 12 (2.6%) appeared in the DPCR with an SUD diagnosis, compared with 46 (2.0%) in the control group (p = 0.41; OR 1.3; 95% CI 0.7-2.5). Specific SUDs occurred with a low frequency in both groups. Only cocaine-related disorders were significantly associated with DLD (p = 0.03). Variables at assessment in childhood, i.e. gender, IQ, the presence of a receptive language disorder, and the degrees of receptive and expressive language disorders were not associated with an SUD diagnosis in the DPCR at follow-up.
Our findings do not support the hypothesis that DLD is a risk factor for SUD in adulthood.
研究童年期被诊断为患有发育性语言障碍（DLD）的成年人中物质使用障碍（SUDs）的患病率及类型。
利用丹麦全国精神病学中央登记处（DPCR）的数据，将469名童年期被诊断为患有DLD的临床样本个体中的SUDs患病率及类型，与2345名来自普通人群且无已知DLD病史的匹配对照者中的SUDs进行比较。平均观察时间为34.7年，随访时的平均年龄为35.8岁。
在469名患有DLD的个体中，有12人（2.6%）在DPCR中被诊断为患有SUD，而对照组中有46人（2.0%）（p = 0.41；OR 1.3；95% CI 0.7 - 2.5）。特定的SUDs在两组中的发生率都很低。只有可卡因相关障碍与DLD显著相关（p = 0.03）。童年期评估时的变量，即性别、智商、接受性语言障碍的存在情况以及接受性和表达性语言障碍的程度，与随访时DPCR中的SUD诊断无关。
我们的研究结果不支持DLD是成年期SUD危险因素这一假设。
