Nippon Institute for Biological Science, 9-2221-1, Shin-Machi, Ome, Tokyo 198-0024, Japan.
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo, Tokyo 113-8657, Japan.
Int J Mol Sci. 2008 Nov;9(11):2146-2158. doi: 10.3390/ijms9112146. Epub 2008 Nov 5.
T-2 toxin is a cytotoxic secondary fungal metabolite that belongs to the trichothecene mycotoxin family. This mycotoxin is a well known inhibitor of protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the ribosomal 60s subunit, and it also inhibits the synthesis of DNA and RNA, probably secondary to the inhibition of protein synthesis. In addition, T-2 toxin is said to induce apoptosis in many types of cells bearing high proliferating activity. T-2 toxin readily passes the placenta and is distributed to embryo/fetal tissues, which include many component cells bearing high proliferating activity. This paper reviews the reported data related to T-2 toxin-induced maternal and fetal toxicities in pregnant mice and rats. The mechanisms of T-2 toxin-induced apoptosis in maternal and fetal tissues are also discussed in this paper.
T-2 毒素是一种细胞毒性的真菌次级代谢产物，属于单端孢霉烯族真菌毒素。这种真菌毒素是一种通过与肽基转移酶的高结合亲和力来抑制蛋白质合成的已知抑制剂，而肽基转移酶是核糖体 60s 亚基的一个组成部分，它还抑制 DNA 和 RNA 的合成，可能是由于蛋白质合成的抑制所致。此外，T-2 毒素据说会诱导许多具有高增殖活性的细胞类型发生细胞凋亡。T-2 毒素很容易穿过胎盘，并分布到胚胎/胎儿组织中，这些组织包括许多具有高增殖活性的细胞成分。本文综述了有关 T-2 毒素在怀孕小鼠和大鼠中引起母体和胎儿毒性的报告数据。本文还讨论了 T-2 毒素在母体和胎儿组织中诱导细胞凋亡的机制。
