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通过mRNA辅助蛋白质折叠发现蛋白质组密码。

Discovery of proteomic code with mRNA assisted protein folding.

作者信息

Biro Jan C

机构信息

Homulus Foundation, 612 S Flower St, Los Angeles, 90 017 CA, USA.

出版信息

Int J Mol Sci. 2008 Dec;9(12):2424-2446. doi: 10.3390/ijms9122424. Epub 2008 Dec 3.

DOI:10.3390/ijms9122424
PMID:19330085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2635648/
Abstract

The 3x redundancy of the Genetic Code is usually explained as a necessity to increase the mutation-resistance of the genetic information. However recent bioinformatical observations indicate that the redundant Genetic Code contains more biological information than previously known and which is additional to the 64/20 definition of amino acids. It might define the physico-chemical and structural properties of amino acids, the codon boundaries, the amino acid co-locations (interactions) in the coded proteins and the free folding energy of mRNAs. This additional information, which seems to be necessary to determine the 3D structure of coding nucleic acids as well as the coded proteins, is known as the Proteomic Code and mRNA Assisted Protein Folding.

摘要

遗传密码的三倍冗余通常被解释为增加遗传信息抗突变能力的必要条件。然而，最近的生物信息学观察表明，冗余的遗传密码包含的生物信息比以前所知的更多，这是除了64/20氨基酸定义之外的额外信息。它可能定义了氨基酸的物理化学和结构特性、密码子边界、编码蛋白质中氨基酸的共定位（相互作用）以及mRNA的自由折叠能。这种额外信息似乎是确定编码核酸以及编码蛋白质的三维结构所必需的，被称为蛋白质组密码和mRNA辅助蛋白质折叠。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/2ff07ac8810e/ijms-09-02424f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/8233860af818/ijms-09-02424f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/bf3d4e21a110/ijms-09-02424f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/4d6c2a928d17/ijms-09-02424f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/718c9bae3737/ijms-09-02424f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/01c11193abca/ijms-09-02424f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/2ff07ac8810e/ijms-09-02424f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/8233860af818/ijms-09-02424f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/bf3d4e21a110/ijms-09-02424f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/4d6c2a928d17/ijms-09-02424f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/718c9bae3737/ijms-09-02424f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/01c11193abca/ijms-09-02424f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1755/2635648/2ff07ac8810e/ijms-09-02424f6.jpg

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Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases.编码序列的核苷酸组成与折叠能之间的相关性，特别关注摆动碱基。
Theor Biol Med Model. 2008 Jul 29;5:14. doi: 10.1186/1742-4682-5-14.
3
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