Centre for Research in Epidemiology and Population Health (CESP), Inserm U1018, Epidemiology of Occupational and Social Determinants of Health Team, F-94807 Villejuif, France.
BMC Cancer. 2013 Nov 28;13:560. doi: 10.1186/1471-2407-13-560.
The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France.
We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case-control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking.
Personal history of oral candidiasis was related to a significantly increased risk of oral cavity cancer (OR 5.0, 95% CI 2.1-12.1). History of head and neck cancers among the first-degree relatives was associated with an OR of 1.9 (95% CI 1.2-2.8). The risk increased with the number of first-degree relatives with head and neck cancer.
A family history of head and neck cancer is a marker of an increased risk of oral cavity cancer and should be taken into account to target prevention efforts and screening. Further studies are needed to clarify the association between oral cavity cancer and personal history of candidiasis.
本研究旨在评估法国口腔癌发病机制中癌症家族史和其他个人病史的作用。
我们使用了一项基于人群的病例对照研究（ICARE 研究）中 689 例口腔鳞状细胞癌病例和 3481 例对照的数据。通过非条件逻辑回归估计与癌症家族史和个人医疗状况相关的比值比（OR）及其 95%置信区间（95%CI），并根据年龄、性别、居住地区、教育程度、体重指数、吸烟和饮酒情况进行调整。
个人口腔念珠菌病史与口腔癌的风险显著增加相关（OR 5.0，95%CI 2.1-12.1）。一级亲属中头颈部癌症史与 OR 为 1.9（95%CI 1.2-2.8）相关。风险随着一级亲属中头颈部癌症患者的数量增加而增加。
头颈部癌症家族史是口腔癌风险增加的标志物，应考虑将其纳入预防工作和筛查的目标。需要进一步研究来阐明口腔癌与个人口腔念珠菌病史之间的关联。
