Campolattaro Matthew M, Freeman John H
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA.
Neurobiol Learn Mem. 2006 Sep;86(2):205-13. doi: 10.1016/j.nlm.2006.03.001. Epub 2006 Apr 17.
The role of the perirhinal cortex in inhibitory eyeblink conditioning was examined. In Experiment 1, rats were given lesions of the perirhinal cortex or control surgery and subsequently trained with a feature-negative discrimination procedure followed by summation and retardation tests for conditioned inhibition. Perirhinal cortex lesions impaired, but did not prevent acquisition of feature-negative discrimination. Results from the summation test showed that rats with perirhinal cortex lesions could not generalize feature-negative discrimination to a new stimulus. There were no group differences during the retardation test. Experiment 2 showed that lesions of the perirhinal cortex did not impair simple excitatory conditioning. Experiment 3 showed that perirhinal cortex lesions had no effect on acquisition of a simple tone-light discrimination. The results suggest that the perirhinal cortex plays a role in eyeblink conditioning when using discrimination procedures involving overlapping stimuli.
研究了嗅周皮质在抑制性眨眼条件反射中的作用。在实验1中，给大鼠进行嗅周皮质损伤或对照手术，随后采用特征负性辨别程序进行训练，接着进行条件性抑制的总和测试和延迟测试。嗅周皮质损伤会损害但不会阻止特征负性辨别的习得。总和测试结果表明，嗅周皮质损伤的大鼠无法将特征负性辨别推广到新刺激上。在延迟测试中没有组间差异。实验2表明，嗅周皮质损伤不会损害简单的兴奋性条件反射。实验3表明，嗅周皮质损伤对简单的音调-灯光辨别习得没有影响。结果表明，当使用涉及重叠刺激的辨别程序时，嗅周皮质在眨眼条件反射中发挥作用。
