Nox5与细胞功能的调节
Nox5 and the regulation of cellular function.
作者信息
Fulton David J R
机构信息
Department of Pharmacology and the Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA.
出版信息
Antioxid Redox Signal. 2009 Oct;11(10):2443-52. doi: 10.1089/ars.2009.2587.
Abstract
The NADPH oxidase (Nox) family of enzymes is comprised of seven members, Noxes 1-5 and the Duoxes 1 and 2. Nox5 was the last of the conventional Nox enzymes to be identified, and in comparison to its siblings, much less is known about its molecular regulation and even less regarding its functional significance. The loss of Nox5 from rodent genomes has contributed significantly to this deficit in knowledge, but recent discoveries have narrowed the gap. There are many differences between Nox5 and the other Nox isoforms including alternative splicing, transcriptional regulation, enzymatic control mechanisms, tissue distribution, and intracellular trafficking. The goal of this review is to outline recent advances in our knowledge of the genetic regulation, the molecular mechanisms governing its activity, and the functional significance of Nox5 in human physiology and pathophysiology.
摘要
烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶（Nox）家族由七个成员组成，即Nox1 - 5以及双氧化酶（Duox）1和2。Nox5是最后一个被鉴定出的传统Nox酶，与其他同类酶相比，人们对其分子调控的了解要少得多，对其功能意义的了解则更少。啮齿动物基因组中Nox5的缺失极大地导致了这一知识空白，但最近的发现缩小了差距。Nox5与其他Nox同工型之间存在许多差异，包括可变剪接、转录调控、酶促控制机制、组织分布和细胞内运输。本综述的目的是概述我们在Nox5的基因调控、其活性的分子机制以及在人类生理和病理生理学中的功能意义方面的最新进展。
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