节段性重复导致人类和黑猩猩之间的基因表达差异。
Segmental duplications contribute to gene expression differences between humans and chimpanzees.
作者信息
Blekhman Ran, Oshlack Alicia, Gilad Yoav
机构信息
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
出版信息
Genetics. 2009 Jun;182(2):627-30. doi: 10.1534/genetics.108.099960. Epub 2009 Mar 30.
Abstract
In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.
摘要
除了顺式和反式调控元件的特定变化外，基因组的结构变化被认为是物种间大量基因表达差异的基础。因此，我们表明物种特异性的节段性重复富含人类和黑猩猩之间差异表达的基因。
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