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Gene regulation in primates evolves under tissue-specific selection pressures.灵长类动物的基因调控在组织特异性选择压力下进化。
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A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications.灵长类片段重复的初步比较分析显示，替换率升高，且染色体内部重复在类人猿中出现扩张。
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A genome-wide comparison of recent chimpanzee and human segmental duplications.近期黑猩猩与人类节段性重复序列的全基因组比较。
Nature. 2005 Sep 1;437(7055):88-93. doi: 10.1038/nature04000.
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Multi-species microarrays reveal the effect of sequence divergence on gene expression profiles.多物种微阵列揭示了序列差异对基因表达谱的影响。
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节段性重复导致人类和黑猩猩之间的基因表达差异。

Segmental duplications contribute to gene expression differences between humans and chimpanzees.

作者信息

Blekhman Ran, Oshlack Alicia, Gilad Yoav

机构信息

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

出版信息

Genetics. 2009 Jun;182(2):627-30. doi: 10.1534/genetics.108.099960. Epub 2009 Mar 30.

DOI:10.1534/genetics.108.099960
PMID:19332884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2691770/
Abstract

In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.

摘要

除了顺式和反式调控元件的特定变化外，基因组的结构变化被认为是物种间大量基因表达差异的基础。因此，我们表明物种特异性的节段性重复富含人类和黑猩猩之间差异表达的基因。